Adult:
Each tablet containing paracetamol 500 mg and metoclopramide 5 mg: >20 yr: Initially, 2 tablets at first warning of an attack. May repeat doses at 4 hrly intervals. Max: 6 tablets/24 hr. 15-20 yr and ≥60 kg: Initially, 2 tablets at first warning of an attack. May repeat doses at 4 hrly intervals. Max: 5 tablets/24 hr. 15-20 yr and 30-59 kg or 12-14 yr and ≥30 kg: Initially, 1 tablet at first warning of an attack. May repeat doses at 4 hrly intervals.
Precautions
Porphyria, epilepsy, parkinsonism, history of depression, pregnancy. Renal or hepatic impairment. May impair ability to drive or operate machinery. Risk of acute hypersensitivity reactions in patients with phaeochromocytoma. Exclude the possibility of an underlying disorder if patient has persistent vomiting.
Potentially Life-threatening
Adverse Drug Reactions
Nausea, allergic reactions, skin rashes, acute renal tubular necrosis. Constipation or diarrhoea; drowsiness, headache, depression, lassitude, extrapyramidal reactions (especially if combined with phenothiazines); galactorrhoea; parkinsonism; neuroleptic malignant syndrome; tardive dyskinesia.
Adverse Drug Reactions
Paracetamol: Very rare, blood dyscrasias (e.g. thrombocytopenia, leucopenia, neutropenia, agranulocytosis); liver damage. Metoclopramide: Very rarely, hypertensive crisis in patients with pheochromocytoma. Cardiac conduction disorders (IV admin).
Interactions
Action of metoclopramide may be antagonised by anticholinergics and opioid analgesics. Metoclopramide may affect the absorption of orally administered drugs when given together.
